Anti-Mouse IL-13 SAFIRE Purified

Grouped product items
Size Price Qty
50ug
$100.00
500ug
$320.00

Additional 1316H Formats

Cat.No. Format Starting From
83512-25 SAFIRE Purified $ 100.00
Catalog Number : 83512-25

description

The 1316H monoclonal antibody binds to mouse IL-13. IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. The 1316H antibody is reported to be a neutralizing antibody.

Additional Information

Clone:
1316H
Format:
SAFIRE Purified
Applications:
FA
Reactivity:
Mouse
Isotype:
Rat IgG1, kappa
Research Interest: Adaptive Immunity
Cell Type: T Cells
Application: FA
Clone: 1316H
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Sasaki, K., Pardee, A. D., Okada, H., & Storkus, W. J. (2008). IL‐4 inhibits VLA‐4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit. European journal of immunology38(10), 2865-2873.

Park, S. H., Chen, W. C., Esmaeil, N., Lucas, B., Marsh, L. M., Reibman, J., & Grunig, G. (2014). Interleukin 13–and interleukin 17A–induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution. Pulmonary circulation4(4), 654.

Blum, L. K., Mohanan, S., Fabre, M. V., Yafawi, R. E., & Appleton, J. A. (2013). Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Veterinary parasitology194(2), 101-105.

 

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