Anti-Mouse IL-12/IL-23 p40 SAFIRE Purified
The C17.8 antibody specifically reacts with the p40 subunit of IL-12, as free monomer, as a homodimer, or as a part of the p70 dimer. C17.8 seems to neutralize the activity of mouse IL-12 and IL-23. IL-12 is the p70 heterodimer of p35 and p40, expressed by the macrophages, dendritic cells, and monocytes. The C17.8 antibody cross-reacts with IL-23, since IL-23 also contains one p40 subunit.
FC, FA, IF, IP, WB, ELISA
Rat IgG2a, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||Macrophage / Monocyte, T Cells, Dendritic Cells|
|Application:||FC, FA, IF, IP, WB, ELISA|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Phosphate-buffered aqueous solution, ph7.2.
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Cho, D., Lee, W. J., Halloran, P. J., Trinchieri, G., & Kim, Y. B. (1996). Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cellular immunology, 172(1), 29-34.
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