Anti-Mouse CD90.2 (Thy-1.2) SAFIRE Purified
The 30-H12 monoclonal antibody specifically binds to Mouse CD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.
The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.
Rat IgG2b, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Cells|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Phosphate-buffered aqueous solution, ph7.2.
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Nakashima, I. Z. U. M. I., Zhang, Y. H., Rahman, S. M., Yoshida, T. O. M. O. A. K. I., Isobe, K. L., Ding, L. N., ... & Taguchi, R. (1991). Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death. The Journal of Immunology, 147(4), 1153-1162.