Anti-Mouse CD90.2 (Thy-1.2) SAFIRE Purified

Grouped product items
SizePrice Qty
50 ug
$100.00
500 ug
$340.00

Additional 30-H12 Formats

Cat.No.FormatStarting From
03012-50FITC$ 25.00
03012-77PE-Cyanine7$ 95.00
03012-80APC$ 65.00
03012-40BG Violet 450$ 75.00
03012-25SAFIRE Purified$ 100.00
Catalog Number : 03012-25

description

The 30-H12 monoclonal antibody specifically binds to Mouse CD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.

The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.

Additional Information

Clone:
30-H12
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest:Adaptive Immunity
Cell Type:T Cells
Application:FC, FA
Clone:30-H12
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*. Immunological reviews47(1), 63-90.

Hathcock, K. (1991). T cell enrichment by cytotoxic elimination of B cells and accessory cells. Current protocols in immunology, 3-3.

Nakashima, I. Z. U. M. I., Zhang, Y. H., Rahman, S. M., Yoshida, T. O. M. O. A. K. I., Isobe, K. L., Ding, L. N., ... & Taguchi, R. (1991). Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death. The Journal of Immunology147(4), 1153-1162.

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