Anti-Mouse CD70 SAFIRE Purified

Grouped product items
SizePrice Qty
50 ug
$100.00
100 ug
$165.00
500 ug
$330.00

Additional FR70 Formats

Cat.No.FormatStarting From
02812-25SAFIRE Purified$ 100.00
Catalog Number : 02812-25

description

The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.

Additional Information

Clone:
FR70
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest:Adaptive Immunity
Cell Type:B Cells, T Cells, Dendritic Cells
Application:FC, FA
Clone:FR70
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., & Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27. The Journal of Immunology159(10), 4959-4965.

Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... & Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb. International immunology10(4), 517-526.

Bullock, T. N., & Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells. The Journal of Immunology174(2), 710-717.

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