Anti-Mouse CD49b (Integrin alpha 2) SAFIRE Purified
Additional HMa2 Formats
Cat.No. | Format | Starting From |
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11512-25 | SAFIRE Purified | $ 570.00 |
Catalog Number : 11512-25
description
The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1). VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.
Additional Information
Clone:
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HMa2
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Format:
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SAFIRE Purified
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Applications:
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FC, FA
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Reactivity:
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Mouse
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Isotype:
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Armenian Hamster IgG
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Research Interest: | Adaptive Immunity, Angiogenesis |
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Cell Type: | T Cells, Macrophage / Monocyte, NK and NKT Cells |
Application: | FC, FA |
Clone: | HMa2 |
Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Arase, H., Saito, T., Phillips, J. H., & Lanier, L. L. (2001). Cutting edge: the mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (α2 integrin, very late antigen-2). The Journal of Immunology, 167(3), 1141-1144. Miyake, S., Sakurai, T., Okumura, K., & Yagita, H. (1994). Identification of collagen and laminin receptor integrins on murine T lymphocytes. European journal of immunology, 24(9), 2000-2005. Noto, K., Kato, K., Okumura, K., & Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb. International immunology, 7(5), 835-842. |