Anti-Mouse CD279 (PD-1) SAFIRE Purified

Grouped product items
SizePrice Qty
50 ug
$120.00
500 ug
$345.00

Additional RMP1-14 Formats

Cat.No.FormatStarting From
31822-25SAFIRE Purified$ 120.00
Catalog Number : 31822-25

description

The RMP1-14 monoclonal antibody specifically reacts with mouse Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The RMP1-14 is reported to block the binding of B7-H1 and B7-DC ligands to the PD-1 receptor.

Additional Information

Clone:
RMP1-14
Format:
SAFIRE Purified
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest:Adaptive Immunity
Cell Type:B Cells, T Cells
Application:FC
Clone:RMP1-14
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Yamazaki, T., Akiba, H., Koyanagi, A., Azuma, M., Yagita, H., & Okumura, K. (2005). Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-γ-induced nitric oxide production. The Journal of Immunology175(3), 1586-1592.

Seko, Y., Yagita, H., Okumura, K., Azuma, M., & Nagai, R. (2007). Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. Cardiovascular research75(1), 158-167.

Martin-Orozco, N., Wang, Y. H., Yagita, H., & Dong, C. (2006). Cutting edge: programed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens. The Journal of Immunology177(12), 8291-8295.

© BioGems International, Inc. All rights reserved.