Anti-Mouse CD279 (PD-1) SAFIRE Purified
Additional RMP1-14 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 31822-25 | SAFIRE Purified | $ 630.00 |
Catalog Number : 31822-25
description
The RMP1-14 monoclonal antibody specifically reacts with mouse Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The RMP1-14 is reported to block the binding of B7-H1 and B7-DC ligands to the PD-1 receptor.
Additional Information
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Clone:
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RMP1-14
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Format:
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SAFIRE Purified
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2a, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | B Cells, T Cells |
| Application: | FC |
| Clone: | RMP1-14 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Yamazaki, T., Akiba, H., Koyanagi, A., Azuma, M., Yagita, H., & Okumura, K. (2005). Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-γ-induced nitric oxide production. The Journal of Immunology, 175(3), 1586-1592. Seko, Y., Yagita, H., Okumura, K., Azuma, M., & Nagai, R. (2007). Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. Cardiovascular research, 75(1), 158-167. Martin-Orozco, N., Wang, Y. H., Yagita, H., & Dong, C. (2006). Cutting edge: programed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens. The Journal of Immunology, 177(12), 8291-8295. |