Anti-Human TNF-alpha SAFIRE Purified

Grouped product items
SizePrice Qty
100 ug
$255.00
1 mg
$800.00

Additional MAb11 Formats

Cat.No.FormatStarting From
84421-20Purified$ 80.00
84421-50FITC$ 245.00
84421-60PE$ 105.00
84421-80APC$ 285.00
84421-25SAFIRE Purified$ 255.00
Catalog Number : 84421-25

description

The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.

Additional Information

Clone:
MAb11
Format:
SAFIRE Purified
Applications:
FC, ELISA, IHC, ICF
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Innate Immunity, Cytokines & Growth Factors, Apoptosis
Cell Type:Th1 cells, Macrophage / Monocyte, NK and NKT Cells, T Cells
Application:FC, ELISA, IHC, ICF
Clone:MAb11
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Danis, V. A., Franic, G. M., Rathjen, D. A., & Brooks, P. M. (1991). Effects of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), IL‐2, interferon‐gamma (IFN‐γ), tumour necrosis factor‐alpha (TNF‐α) and IL‐6 on the production of immunoreactive IL‐1 and TNF‐α by human monocytes. Clinical & Experimental Immunology85(1), 143-150.

Prussin, C., & Metcalfe, D. D. (1995). Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. Journal of immunological methods188(1), 117-128.

Andersen, H., Rossio, J. L., Coalter, V., Poore, B., Martin, M. P., Carrington, M., & Lifson, J. D. (2004). Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level. Cellular immunology231(1), 85-95.

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