Anti-Human TIM3 SAFIRE Purified

Grouped product items
SizePrice Qty
500ug
$470.00

Additional F38-2E2 Formats

Cat.No.FormatStarting From
78211-80APC$ 130.00
78211-25SAFIRE Purified$ 470.00
78211-77PE-Cyanine7$ 185.00
Catalog Number : 78211-25

description

The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection.

Additional Information

Clone:
F38-2E2
Format:
SAFIRE Purified
Applications:
FA
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Adaptive Immunity
Cell Type:Macrophage / Monocyte, T Cells, T Regulatory Cells, Th17 cells
Application:FA
Clone:F38-2E2
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Klibi, J., Niki, T., Riedel, A., Pioche-Durieu, C., Souquere, S., Rubinstein, E., ... & Busson, P. (2009). Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells. Blood113(9), 1957-1966.

Hastings, W. D., Anderson, D. E., Kassam, N., Koguchi, K., Greenfield, E. A., Kent, S. C., ... & Kuchroo, V. K. (2009). TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European journal of immunology39(9), 2492-2501.

Koguchi, K., Anderson, D. E., Yang, L., O'Connor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006). Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of experimental medicine203(6), 1413-1418.

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