Anti-Human/Mouse CD44 SAFIRE Purified

Grouped product items
SizePrice Qty
50 ug
$110.00
100 ug
$175.00
500 ug
$310.00
1 mg
$530.00

Additional IM7 Formats

Cat.No.FormatStarting From
06511-60PE$ 55.00
06511-65PE-Cyanine5$ 70.00
06511-70PerCP-Cyanine5.5 $ 85.00
06511-40BG Violet 450$ 80.00
06511-20Purified$ 130.00
06511-50FITC$ 55.00
06511-87APC-Cyanine7 $ 75.00
06511-80APC$ 60.00
06511-77PE-Cyanine7$ 75.00
06511-25SAFIRE Purified$ 110.00
Catalog Number : 06511-25

description

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.

The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.

The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

Additional Information

Clone:
IM7
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Human, Mouse
Isotype:
Rat IgG2b, kappa
Cell Type:Stem Cells, Macrophage / Monocyte
Application:FC, FA
Clone:IM7
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312.

Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics15(3), 313-320.

Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity13(1), 39-47.

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