Anti-Human CD16 SAFIRE Purified

Grouped product items
SizePrice Qty
100 ug
$220.00
500 ug
$430.00

Additional 3G8 Formats

Cat.No.FormatStarting From
08221-50FITC$ 125.00
08221-25SAFIRE Purified$ 220.00
08221-60PE$ 110.00
Catalog Number : 08221-25

description

The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils.

Additional Information

Clone:
3G8
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Innate Immunity
Cell Type:Macrophage / Monocyte, NK and NKT Cells
Application:FC, FA
Clone:3G8
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ph7.2
References:
Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008). Use of an anti‐CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. Immunology124(2), 215-222.

Perussia, B. I. C. E., & Trinchieri, G. I. O. R. G. I. O. (1984). Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells. The Journal of Immunology132(3), 1410-1415.

Vossebeld, P. J., Homburg, C. H., Roos, D., & Verhoeven, A. J. (1997). The anti-FcγRIII mAb 3G8 induces neutrophil activation via a cooperative action of FcγRIIIb and FcγRIIa. The international journal of biochemistry & cell biology,29(3), 465-473.

© BioGems International, Inc. All rights reserved.