Anti-Human CD152 (CTLA-4) SAFIRE Purified
The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
Mouse IgG2a, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Regulatory Cells, T Cells|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Phosphate-buffered aqueous solution, ph7.2.
Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., & van der Merwe, P. A. (1997). The leucocyte antigen factsbook. Academic Press.
Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., ... & Gray, G. S. (1993). Characterization of CTLA-4 structure and expression on human T cells. The Journal of Immunology, 151(7), 3489-3499.
Kuiper, H. M., Brouwer, M., Linsley, P. S., & Van Lier, R. A. (1995). Activated T cells can induce high levels of CTLA-4 expression on B cells. The Journal of Immunology, 155(4), 1776-1783.