Anti-Mouse ROR gamma Purified

Grouped product items
SizePrice Qty
25ug
$145.00
100ug
$320.00

Additional RORg2 Formats

Cat.No.FormatStarting From
77612-20Purified$ 145.00
Catalog Number : 77612-20

description

The Retinoid-related orphan receptor gamma is in the nuclear hormone receptor of transcription factors and is produced as two isoforms, gamma1 and gamma2. The isoforms differ through the n-terminus. It is reported that Th17 cells utilize this receptor to specify their differentiation and lineage-specific function. The transcription factor is essential for lymphoid organogenesis, in particular lymph nodes and Peyer's patches, but not the spleen. It also plays a role in inhibiting apoptosis of undifferentiated T cells and promoting their differentiation into Th17 cells, possibly by down regulating the expression of Fas ligand and IL2, respectively.

Additional Information

Clone:
RORg2
Format:
Purified
Applications:
FA
Reactivity:
Mouse
Isotype:
Armenian hamster IgG
Cell Type:T Cells
Application:FA
Clone:RORg2
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Ruan, Q., Kameswaran, V., Zhang, Y., Zheng, S., Sun, J., Wang, J., ... & Chen, Y. H. (2011). The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis. The Journal of experimental medicine,208(11), 2321-2333.

Jetten, A. M. (2009). Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal7(3).

He, Y. W., Deftos, M. L., Ojala, E. W., & Bevan, M. J. (1998). RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity9(6), 797-806.

Sun, Z., Unutmaz, D., Zou, Y. R., Sunshine, M. J., Pierani, A., Brenner-Morton, S., ... & Littman, D. R. (2000). Requirement for RORγ in thymocyte survival and lymphoid organ development. Science288(5475), 2369-2373.

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