Anti-Human TNF-alpha Purified

Grouped product items
Size	Price	Qty
50 ug	$145.00
500 ug	$420.00

Additional MAb11 Formats

Cat.No.	Format	Starting From
84421-20	Purified	$ 145.00

Catalog Number : 84421-20

description

The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.

Additional Information

Clone:	MAb11
Format:	Purified
Applications:	FC, ELISA, IHC, ICF
Reactivity:	Human
Isotype:	Mouse IgG1, kappa
Research Interest:	Innate Immunity, Apoptosis, Cytokines & Growth Factors
Cell Type:	T Cells, Macrophage / Monocyte, NK and NKT Cells, Th1 cells
Application:	FC, ELISA, IHC, ICF
Clone:	MAb11
Preparation:	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Danis, V. A., Franic, G. M., Rathjen, D. A., & Brooks, P. M. (1991). Effects of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), IL‐2, interferon‐gamma (IFN‐γ), tumour necrosis factor‐alpha (TNF‐α) and IL‐6 on the production of immunoreactive IL‐1 and TNF‐α by human monocytes. Clinical & Experimental Immunology, 85(1), 143-150. Prussin, C., & Metcalfe, D. D. (1995). Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. Journal of immunological methods, 188(1), 117-128. Andersen, H., Rossio, J. L., Coalter, V., Poore, B., Martin, M. P., Carrington, M., & Lifson, J. D. (2004). Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level. Cellular immunology, 231(1), 85-95.