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Anti-Human CD197 (CCR7) Purified



Catalog Number : 20011-20

Description

The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled. It is the receptor for the secondary lymphoid-tissue chemokine (SLC or 6CKine), CCL19, and CCL21. CD197 is expressed on subsets of B and T cells, and mature dendritic cells. The monoclonal 3D12 antibody recognizes the N-terminus of the receptor.

We recommend that this antibody be incubated for at least 45 minutes at 4°C for optimal staining.

Additional Information

Clone:
3D12
Format:
Purified
Applications:
FC, IHC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: B Cells, T Cells, Dendritic Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature401(6754), 708-712.

Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., ... & Yoshie, O. (1998). EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC. International immunology10(7), 901-910.

Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., López-Botet, M., & Geraghty, D. E. (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proceedings of the National Academy of Sciences,95(9), 5199-5204.


Availability: In stock

Size Price Qty
100ug
$165.00
Additional 3D12 Formats
Cat.No. Format Starting From
20011-50FITC $ 110.00
20011-60PE $ 110.00
20011-20Purified $ 165.00