Anti-Human CD178 (Fas-L) Purified

Grouped product items
Size	Price	Qty
100 ug	$220.00

Additional NOK-1 Formats

Cat.No.	Format	Starting From
20811-80	APC	$ 110.00
20811-30	Biotin	$ 90.00
20811-20	Purified	$ 220.00
20811-25	SAFIRE Purified	$ 225.00

Catalog Number : 20811-20

description

The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.

Additional Information

Clone:	NOK-1
Format:	Purified
Applications:	FC, IP, FA, WB
Reactivity:	Human
Isotype:	Mouse IgG1, kappa
Research Interest:	Apoptosis, Cancer
Cell Type:	T Cells, NK and NKT Cells
Application:	FC, IP, FA, WB
Clone:	NOK-1
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., ... & Yagita, H. (1995). Metalloproteinase-mediated release of human Fas ligand.The Journal of experimental medicine, 182(6), 1777-1783. Oyaizu, N., Adachi, Y., Hashimoto, F., McCloskey, T. W., Hosaka, N., Kayagaki, N., ... & Pahwa, S. (1997). Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. The Journal of Immunology, 158(5), 2456-2463. Villunger, A., Egle, A., Marschitz, I., Kos, M., Böck, G., Ludwig, H., ... & Greil, R. (1997). Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance. Blood, 90(1), 12-20.