Anti-Rat CD86 (B7-2) FITC
The 24F monoclonal antibody specifically reacts with CD86 (B7-2), a 90 kDA surface receptor present on antigen presenting cells and activated B and T cells. CD86 is a ligand for CD28 and CD152 and plays an essential role in B cell-T cell costimulatory interactions.
The 24F antibody is capable of blocking the co-stimulatory activity of CD86.
Mouse IgG1, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||Dendritic Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Maeda, K., Sato, T., Azuma, M., Yagita, H., & Okumura, K. (1997). Characterization of rat CD80 and CD86 by molecular cloning and mAb.International immunology, 9(7), 993-1000.
Damoiseaux, J. G., Yagita, H., Okumura, K., & van Breda Vriesman, P. J. (1998). Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells. Journal of leukocyte biology, 64(6), 803-809.
BLUESTONE, J. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity, 2, 555-559.