Anti-Rat CD45R (B220) FITC
Catalog Number : 07113-50
description
The HIS24 monoclonal antibody specifically reacts with an isoform of the rat CD45 glycoprotein. CD45R/B220 is expressed on all the development stages of B cells to the exclusion of plasma cells. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The HIS24 antibody is useful as a marker for the identification of B-cell progenitors.
Additional Information
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Clone:
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HIS24
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Format:
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FITC
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Applications:
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FC
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Reactivity:
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Rat
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Isotype:
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mouse IgG2b, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | B Cells, T Cells |
| Application: | FC |
| Clone: | HIS24 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Hermans, M. H. A., Deenen, G. J., De Boer, N., Bo, W., Kroese, F. G. M., & Opstelten, D. (1997). Expression of HIS50 Ag: a rat homologue of mouse heat‐stable antigen and human CD24 on B lymphoid cells in the rat. Immunology,90(1), 14-22. Kroese, F. G., Butcher, E. C., Lalor, P. A., Stall, A. M., & Herzenberg, L. A. (1990). The rat B cell system: The anatomical localization of flow cytometry‐defined B cell subpopulations. European journal of immunology, 20(7), 1527-1534.Kroese, F. G. M., Opstelten, D., Wubbena, A. S., Deenen, G. J., Aten, J., Schwander, E. H., ... & Nieuwenhuis, P. (1985). Monoclonal antibodies to rat B lymphocyte (sub-) populations. In Microenvironments in the Lymphoid System(pp. 81-89). Springer US. |