Anti-Rat CD3 FITC

Grouped product items
Size	Price	Qty
50 ug	$80.00
100 ug	$140.00
500 ug	$300.00

Additional G4.18 Formats

Cat.No.	Format	Starting From
05113-50	FITC	$ 80.00
05113-25	SAFIRE Purified	$ 350.00
05113-60	PE	$ 90.00

Catalog Number : 05113-50

description

The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR). CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.

Additional Information

Clone:	G4.18
Format:	FITC
Applications:	FC
Reactivity:	Rat
Isotype:	Mouse IgG3, kappa
Research Interest:	Adaptive Immunity
Cell Type:	NK and NKT Cells
Application:	FC
Clone:	G4.18
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Nicolls, M. R., Aversa, G. G., Pearce, N. W., Spinelli, A., Berger, M. F., Gurley, K. E., & Hall, B. M. (1993). Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.Transplantation, 55(3), 459-468. Morris, D. L., & Komocsar, W. J. (1997). Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats.Journal of pharmacological and toxicological methods, 37(1), 37-46. Tran, G. T., Carter, N., He, X. Y., Spicer, T. S., Plain, K. M., Nicolls, M., ... & Hodgkinson, S. J. (2001). Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4. International immunology, 13(9), 1109-1120.