Anti-Mouse F4/80 Antigen APC
The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.
Rat IgG2a, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||Macrophage / Monocyte, Dendritic Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Zwadlo, G., Bröcker, E. B., Von Bassewitz, D. B., Feige, U., & Sorg, C. (1985). A monoclonal antibody to a differentiation antigen present on mature human macrophages and absent from monocytes. The Journal of Immunology, 134(3), 1487-1492.
Leenen, P. J., de Bruijn, M. F., Voerman, J. S., Campbell, P. A., & van Ewijk, W. (1994). Markers of mouse macrophage development detected by monoclonal antibodies. Journal of immunological methods, 174(1), 5-19.
Schaller, E., Macfarlane, A. J., Rupec, R. A., Gordon, S., McKnight, A. J., & Pfeffer, K. (2002). Inactivation of the F4/80 glycoprotein in the mouse germ line.Molecular and cellular biology, 22(22), 8035-8043.