Anti-Mouse Perforin APC

Grouped product items
SizePrice Qty
25 ug
$170.00

Additional OMAK-D Formats

Cat.No.FormatStarting From
84812-80APC$ 170.00
Catalog Number : 84812-80

description

The OMAK-D monoclonal antibody reacts with mouse perforin, a 70kDA cytolytic protein also known as PFP, Cytolysin and PRF. It is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTL) and NK cells and used to mediate targeted cell lysis. The OMAK-D antibody is cross-reactive with human perforin.

Additional Information

Clone:
OMAK-D
Format:
APC
Applications:
FC
Reactivity:
Mouse
Isotype:
IgG2a, kappa
Research Interest:Innate Immunity, Adaptive Immunity, Apoptosis
Cell Type:NK and NKT Cells, T Cells
Application:FC
Clone:OMAK-D
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Opferman, J. T., Ober, B. T., & Ashton-Rickardt, P. G. (1999). Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science,283(5408), 1745-1748.

Walsh, C. M., Matloubian, M., Liu, C. C., Ueda, R., Kurahara, C. G., Christensen, J. L., ... & Clark, W. R. (1994). Immune function in mice lacking the perforin gene. Proceedings of the National Academy of Sciences91(23), 10854-10858.

Fehniger, T. A., Cai, S. F., Cao, X., Bredemeyer, A. J., Presti, R. M., French, A. R., & Ley, T. J. (2007). Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.Immunity26(6), 798-811.

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