Anti-Mouse IL-2 Biotin
The JES6-5H4 antibody specifically binds to mouse IL-2, a 17 kDa immunoregulatory cytokine and growth factor for T and B lymphocytes, NK cells, monocytes, and macrophages. IL-2 induces the cytotoxic operations of NK cells, activates B cells, and plays a role in the differentiation of T cells.
JES6-5H4 seems to have a neutralizing effect on interleukin-2.
Rat IgG2b, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Cells, T Regulatory Cells, Th1 cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Sander, B., Höidén, I., Andersson, U., Möller, E., & Abrams, J. S. (1993). Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen: Cytokine detection by immunoassay and intracellular immunostraining. Journal of immunological methods, 166(2), 201-214.
Abrams, J. S., Roncarolo, M. G., Yssel, H., Andersson, U., Gleich, G. J., & Silver, J. E. (1992). Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunological reviews, 127(1), 5-24.
Abrams, J. S. (1995). Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies (pp. 6-20). John Wiley & Sons, Inc..