Anti-Mouse Foxp3 APC
The 3G3 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression.
Mutations of Foxp3 result in the “scurfy” mice phenotype.
Mouse IgG1, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Regulatory Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Nagar, M., Vernitsky, H., Cohen, Y., Dominissini, D., Berkun, Y., Rechavi, G., ... & Goldstein, I. (2008). Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25− CD4+ T cells. International immunology, 20(8), 1041-1055.
Bolzer, K., Käser, T., Saalmüller, A., & Hammer, S. E. (2009). Molecular characterisation of porcine Forkhead-box p3 (< i> Foxp3</i>). Veterinary immunology and immunopathology, 132(2), 275-281.
Gavin, M. A., Torgerson, T. R., Houston, E., Ho, W. Y., Stray-Pedersen, A., Ocheltree, E. L., ... & Rudensky, A. Y. (2006). Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proceedings of the National Academy of Sciences, 103(17), 6659-6664.