Anti-Mouse CD90.2 APC
Additional 30-H12 Formats
Cat.No. | Format | Starting From |
---|---|---|
03012-50 | FITC | $ 25.00 |
03012-77 | PE-Cyanine7 | $ 95.00 |
03012-80 | APC | $ 65.00 |
03012-40 | BG Violet 450 | $ 75.00 |
03012-25 | SAFIRE Purified | $ 580.00 |
description
The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.
The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.
Additional Information
Clone:
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30-H12
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2b
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Research Interest: | Adaptive Immunity |
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Cell Type: | T Cells |
Application: | FC |
Clone: | 30-H12 |
Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*. Immunological reviews, 47(1), 63-90. Radrizzani, M., Carminatti, H., Pivetta, O. H., & Vargas, V. P. (1995). Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research, 42(2), 220-227. Seaman, W. E., Wofsy, D., Greenspan, J. S., & Ledbetter, J. A. (1983). Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology, 130(4), 1713-1718. |