Anti-Mouse CD90.2 APC

Grouped product items
SizePrice Qty
25 μg
$65.00
100 μg
$205.00

Additional 30-H12 Formats

Cat.No.FormatStarting From
03012-50FITC$ 25.00
03012-77PE-Cyanine7$ 95.00
03012-80APC$ 65.00
03012-40BG Violet 450$ 75.00
03012-25SAFIRE Purified$ 100.00
Catalog Number : 03012-80

description

The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.

The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.

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C57Bl/6 splenocytes were stained with APC 30-H12 with relevant isotype control in Red.
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Additional Information

Clone:
30-H12
Format:
APC
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2b
Research Interest:Adaptive Immunity
Cell Type:T Cells
Application:FC
Clone:30-H12
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*. Immunological reviews47(1), 63-90.

Radrizzani, M., Carminatti, H., Pivetta, O. H., & Vargas, V. P. (1995). Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research42(2), 220-227.

Seaman, W. E., Wofsy, D., Greenspan, J. S., & Ledbetter, J. A. (1983). Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology130(4), 1713-1718.

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