Anti-Mouse CD49b (Integrin alpha 2) FITC

Grouped product items
SizePrice Qty
50 ug
$115.00
500 ug
$330.00

Additional DX5 Formats

Cat.No.FormatStarting From
11532-50FITC$ 115.00
Catalog Number : 11532-50

description

The DX5 monoclonal antibody specifically binds with mouse CD49b, a 150kDA integrin alpha chain that forms the VLA-2 complex with CD29 (integrin beta 1). CD49b is expressed on most mouse NK cells, platelets, NKT cells, and a subset of T cells. The DX5 antibody has been reported to been used to distinguish functional subset of NK cells, as it can be used to identify mouse NK cells that do not exhibit the NK1.1 antigen.

Additional Information

Clone:
DX5
Format:
FITC
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgM, kappa
Research Interest:Angiogenesis, Innate Immunity
Cell Type:T Cells, NK and NKT Cells, Macrophage / Monocyte
Application:FC
Clone:DX5
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Arase, H., Saito, T., Phillips, J. H., & Lanier, L. L. (2001). Cutting edge: the mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (α2 integrin, very late antigen-2). The Journal of Immunology167(3), 1141-1144.

Fernandez, N. C., Lozier, A., Flament, C., Ricciardi-Castagnoli, P., Bellet, D., Suter, M., ... & Zitvogel, L. (1999). Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.Nature medicine5(4), 405-411.

Gadue, P., & Stein, P. L. (2002). NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. The Journal of Immunology169(5), 2397-2406.

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