Anti-Mouse CD4 PE

Grouped product items
SizePrice Qty
25 μg
$30.00
100 μg
$65.00

Additional RM4-5 Formats

Cat.No.FormatStarting From
06122-60PE$ 30.00
06122-70PerCP-Cyanine5.5 $ 80.00
06122-77PE-Cyanine7$ 70.00
06122-40BG Violet 450$ 75.00
06122-50FITC$ 30.00
06122-87APC-Cyanine7 $ 65.00
06122-80APC$ 65.00
06122-45BG Violet 500$ 85.00
Catalog Number : 06122-60

description

The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).

Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.

product image
C57Bl/6 splenocytes were stained with PE RM4-5 with relevant isotype control in Red.
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Additional Information

Clone:
RM4-5
Format:
PE
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest:Adaptive Immunity
Cell Type:Macrophage / Monocyte, T Cells, T Regulatory Cells, Th17 cells
Application:FC
Clone:RM4-5
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Shevach, E. M. (2000). Regulatory T cells in autoimmmunity*. Annual review of immunology18(1), 423-449.

Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., & Shortman, K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.

Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., & Appleton, J. A. (2007). IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. The Journal of Immunology178(12), 7974-7983.

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