Anti-Mouse CD4 PE
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).
Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.
Rat IgG2a, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||Macrophage / Monocyte, T Cells, T Regulatory Cells, Th17 cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Shevach, E. M. (2000). Regulatory T cells in autoimmmunity*. Annual review of immunology, 18(1), 423-449.
Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., & Shortman, K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., & Appleton, J. A. (2007). IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. The Journal of Immunology, 178(12), 7974-7983.