Anti-Mouse CD4 BG Violet 450

Grouped product items
SizePrice Qty
25 μg
$75.00
100 μg
$175.00

Additional RM4-5 Formats

Cat.No.FormatStarting From
06122-60PE$ 30.00
06122-70PerCP-Cyanine5.5 $ 80.00
06122-77PE-Cyanine7$ 70.00
06122-40BG Violet 450$ 75.00
06122-50FITC$ 30.00
06122-87APC-Cyanine7 $ 65.00
06122-80APC$ 65.00
06122-45BG Violet 500$ 85.00
Catalog Number : 06122-40

description

The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).

Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.

BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Additional Information

Clone:
RM4-5
Format:
BG Violet 450
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest:Adaptive Immunity
Cell Type:Macrophage / Monocyte, T Cells, T Regulatory Cells, Th17 cells
Application:FC
Clone:RM4-5
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Shevach, E. M. (2000). Regulatory T cells in autoimmmunity*. Annual review of immunology18(1), 423-449.

Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., & Shortman, K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.

Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., & Appleton, J. A. (2007). IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. The Journal of Immunology178(12), 7974-7983.

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