Anti-Mouse CD335 (NKp46) Biotin
The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule. It is expressed in only NK and a rare subset of NK-like T cells, not including the CD1d-restricted NKT division. CD335 is active during NK lysis of pathogen-infected and tumor cells.
The 29A1.4 in vitro activates NK cells, but does not deplete NK cells in vivo.
Rat IgG2b, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||NK and NKT Cells|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Walzer, T., Bléry, M., Chaix, J., Fuseri, N., Chasson, L., Robbins, S. H., ... & Vivier, E. (2007). Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proceedings of the National Academy of Sciences, 104(9), 3384-3389.
Joncker, N. T., Fernandez, N. C., Treiner, E., Vivier, E., & Raulet, D. H. (2009). NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model. The Journal of Immunology,182(8), 4572-4580.
Gazit, R., Gruda, R., Elboim, M., Arnon, T. I., Katz, G., Achdout, H., ... & Mandelboim, O. (2006). Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nature immunology, 7(5), 517-523.