Anti-Mouse CD197 (CCR7) PE

Grouped product items
SizePrice Qty
25ug
$110.00
100 ug
$275.00

Additional 4B12 Formats

Cat.No.FormatStarting From
20012-60PE$ 110.00
Catalog Number : 20012-60

description

The 4B12 monoclonal antibody specifically reacts with mouse CD197 (CCR7), a seven-transmembrane G-protein-coupled glycoprotein. CD197 is a receptor thought to be a mediator of EBV effects on B lymphocytes. It is expressed on lymphoid tissue and is known to activate B and T lymphocytes and stimulate dendritic cell maturation. It often serves as a homing receptor that is used to guide various cell types to and within lymphoid tissue. The 4B12 antibody is not reported to block the binding of CCL21 to CCR7. We recommend that the cell staining done with this antibody be conducted at 37°C.

Additional Information

Clone:
4B12
Format:
PE
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest:Innate Immunity
Cell Type:B Cells, T Cells, Dendritic Cells
Application:FC
Clone:4B12
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Britschgi, M. R., Link, A., Lissandrin, T. K. A., & Luther, S. A. (2008). Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo. The Journal of Immunology181(11), 7681-7688.

Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., ... & Förster, R. (2004). CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity21(2), 279-288.

Ritter, U., Wiede, F., Mielenz, D., Kiafard, Z., Zwirner, J., & Körner, H. (2004). Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells. Journal of leukocyte biology76(2), 472-476.

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