Anti-Mouse CD284 (TLR4) PE

Grouped product items
SizePrice Qty
25 ug
$130.00

Additional UT41 Formats

Cat.No.FormatStarting From
26912-60PE$ 130.00
Catalog Number : 26912-60

description

The UT41 monoclonal antibody specifically reacts with mouse CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). The complex of TLR-4, MD-2, and CD14 regulates the innate immune system recognition of bacterial lipopolysaccharides (LPS) and is expressed on the surface of thioglycollate-elicited macrophages. The UT41 antibody can bind to TLR4 with or without the formation of the TLR4/MD-2 complex.

Additional Information

Clone:
UT41
Format:
PE
Applications:
FC
Reactivity:
Mouse
Isotype:
Mouse IgG1
Research Interest:Innate Immunity
Cell Type:Macrophage / Monocyte
Application:FC
Clone:UT41
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Yang, D., Liu, Y., Chen, Y., Jiao, D., Hou, X., Wang, L., & Fu, N. (2012). Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.International journal of molecular medicine29(6), 1072.

Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., ... & Akira, S. (2000). Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. The Journal of Immunology164(7), 3476-3479.

Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Mühlradt, P. F., Takeda, K., & Akira, S. (2000). Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways. The Journal of Immunology165(12), 7096-7101.

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