Anti-Mouse CD282 (TLR2) FITC

Grouped product items
SizePrice Qty
25 ug
$130.00
100 ug
$310.00

Additional mT2.7 Formats

Cat.No.FormatStarting From
24912-50FITC$ 130.00
Catalog Number : 24912-50

description

The mT2.7 monoclonal antibody specifically reacts with mouse CD282, the Toll-like receptor 2 (TLR2). It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on monocytes, macrophages, dendritic cells, and the RAW264.7 cell line and is involved distinguishing bacterial lipoproteins.

Additional Information

Clone:
mT2.7
Format:
FITC
Applications:
FC
Reactivity:
Mouse
Isotype:
Mouse IgG2a, kappa
Research Interest:Innate Immunity
Cell Type:Macrophage / Monocyte, Dendritic Cells
Application:FC
Clone:mT2.7
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Vinnakota, K., Hu, F., Ku, M. C., Georgieva, P. B., Szulzewsky, F., Pohlmann, A., ... & Kettenmann, H. (2013). Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. Neuro-oncology,15(11), 1457-1468.

Meng, G., Rutz, M., Schiemann, M., Metzger, J., Grabiec, A., Schwandner, R., ... & Kirschning, C. J. (2004). Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes. Journal of Clinical Investigation113(10), 1473-1481.

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