Anti-Mouse CD282 (TLR2) FITC
Catalog Number : 24912-50
description
The mT2.7 monoclonal antibody specifically reacts with mouse CD282, the Toll-like receptor 2 (TLR2). It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on monocytes, macrophages, dendritic cells, and the RAW264.7 cell line and is involved distinguishing bacterial lipoproteins.
Additional Information
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Clone:
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mT2.7
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Format:
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FITC
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Mouse IgG2a, kappa
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| Research Interest: | Innate Immunity |
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| Cell Type: | Macrophage / Monocyte, Dendritic Cells |
| Application: | FC |
| Clone: | mT2.7 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Vinnakota, K., Hu, F., Ku, M. C., Georgieva, P. B., Szulzewsky, F., Pohlmann, A., ... & Kettenmann, H. (2013). Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. Neuro-oncology,15(11), 1457-1468. Meng, G., Rutz, M., Schiemann, M., Metzger, J., Grabiec, A., Schwandner, R., ... & Kirschning, C. J. (2004). Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes. Journal of Clinical Investigation, 113(10), 1473-1481. |