Anti-Mouse CD274 (PD-L1, B7-H1) PE
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.
Rat IgG2b, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||B Cells, T Cells, NK and NKT Cells, Macrophage / Monocyte|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A., ... & Sharpe, A. H. (2011). The programmed death-1 ligand 1: B7-1 pathway restrains diabetogenic effector T cells in vivo. The Journal of Immunology, 187(3), 1097-1105
Koehn, B. H., Ford, M. L., Ferrer, I. R., Borom, K., Gangappa, S., Kirk, A. D., & Larsen, C. P. (2008). PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. The Journal of Immunology, 181(8), 5313-5322.
Maier, H., Isogawa, M., Freeman, G. J., & Chisari, F. V. (2007). PD-1: PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver. The Journal of Immunology, 178(5), 2714-2720.