Anti-Mouse CD252 (OX40L) Biotin
Catalog Number : 24611-30
description
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.
Additional Information
Clone: | RM134L |
Format: | Biotin |
Applications: | FC |
Reactivity: | Mouse |
Isotype: | Rat IgG2b, kappa |
| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | B Cells, Dendritic Cells |
| Application: | FC |
| Clone: | RM134L |
Preparation: | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted biotin was removed from the product. |
Formulation: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
References: | Stüber, E., Neurath, M., Calderhead, D., Perry Fell, H., & Strober, W. (1995). Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity,2(5), 507-521. Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., ... & Okumura, K. (1999). CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. The Journal of Immunology, 162(12), 7058-7066. Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., & Fell, H. P. (1993). Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions. The Journal of Immunology,151(10), 5261-5271. |