Anti-Mouse CD16 / CD32 PE

Grouped product items
SizePrice Qty
25 ug
$60.00
100 ug
$170.00

Additional 2.4G2 Formats

Cat.No.FormatStarting From
08212-20Purified$ 100.00
08212-25SAFIRE Purified$ 135.00
08212-50FITC$ 55.00
08212-30Biotin$ 55.00
08212-60PE$ 60.00
08212-77PE-Cyanine7$ 65.00
Catalog Number : 08212-60

description

The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc γ III) and CD 32 (Fc γ II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.

The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc γ I receptor.

Additional Information

Clone:
2.4G2
Format:
PE
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2b
Research Interest:Innate Immunity
Cell Type:NK and NKT Cells, Macrophage / Monocyte
Application:FC
Clone:2.4G2
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Araujo-Jorge, T. A. N. I. A., Rivera, M. T., el Bouhdidi, A. Y. A. C. H. I., Daëron, M. A. R. C., & Carlier, Y. (1993). An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4 G2) decreases acute Trypanosoma cruzi infection in mice. Infection and immunity61(11), 4925-4928.

Jensen, W. A., Marschner, S., Ott, V. L., & Cambier, J. C. (2001). FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization. Biochemical Society Transactions29(Pt 6), 840-846.

Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L., & Shortman, K. (1992). The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. The Journal of experimental medicine176(1), 47-58.

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