Anti-Mouse CD135 (Flt3) PE

Grouped product items
Size Price Qty
50 ug
$120.00
100 ug
$210.00

Additional A2F10 Formats

Cat.No. Format Starting From
17412-60 PE $ 120.00
17412-20 Purified $ 65.00
Catalog Number : 17412-60

description

The A2F10 monoclonal antibody specifically reacts with mouse CD135, a tyrosine kinase class III receptor. CD135, also known as Flt3, Ly-72, and Flk-2, is the receptor for the FLT3 ligand (FLT3L) cytokine and is expressed on many hematopoietic progenitor cells. Signaling through CD135 plays a role in cell survival, proliferation, and differentiation. The A2F10 antibody is reported to inhibit the binding of FLT3L to CD135.

Additional Information

Clone:
A2F10
Format:
PE
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest: Stem Cell Research
Cell Type: Stem Cells
Application: FC
Clone: A2F10
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Zurawski, S., Kastelein, R., ... & Lee, F. (1994). Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.

Ogawa, M., Sugawara, S., Kunisada, T., Sudo, T., Hayashi, S. I., Nishikawa, S., & Kodama, H. (1998). Flt3/Flk-2 and c-Kit are not essential for the proliferation of B lymphoid progenitor cells in the bone marrow of the adult mouse. Experimental hematology26(6), 478-488.

Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., & Lemischka, I. R. (1991). A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell65(7), 1143-1152.

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