Anti-Mouse CD117 (c-Kit) APC
The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.
Rat IgG2b, kappa
|Protein Cross Reactivity:||Rat|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Godfrey, D. I., Kennedy, J., Mombaerts, P., Tonegawa, S., & Zlotnik, A. (1994). Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8-thymocyte differentiation. The Journal of Immunology, 152(10), 4783-4792.
Godfrey, D. I., Zlotnik, A. L. B. E. R. T., & Suda, T. A. K. A. S. H. I. (1992). Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. The Journal of Immunology, 149(7), 2281-2285.
Feng, H., Sandlow, J. I., & Sandra, A. (1998). The c-kit receptor and its possible signaling transduction pathway in mouse spermatozoa. Molecular reproduction and development, 49(3), 317-326.