Anti-Human Perforin PE
Catalog Number : 84811-60
description
The dG9 monoclonal antibody specifically reacts with human perforin, a cytolytic mediator found in the cytoplasmic granules of cytotoxic T (CTL) and natural killer (NK) cells. Perforin is integral molecule in targeted cell lysis and utilized in the immune system’s reaction to tumors and virus infections.
Additional Information
Clone: | dG9 (delta G9) |
Format: | PE |
Applications: | FC |
Reactivity: | Human |
Isotype: | IgG2b, kappa |
| Research Interest: | Innate Immunity, Adaptive Immunity, Apoptosis |
|---|---|
| Cell Type: | NK and NKT Cells, T Cells |
| Application: | FC |
| Clone: | dG9 (delta G9) |
Preparation: | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Formulation: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
References: | Hameed, A., Olsen, K. J., Cheng, L., Fox 3rd, W. M., Hruban, R. H., & Podack, E. R. (1992). Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody. The American journal of pathology, 140(5), 1025. Schlesinger, B. C., & Cheng, L. (1994). Characterization of a novel monoclonal antibody against human perforin using transfected cell lines. Immunology, 81(2), 291. Wood, S. M., Meeths, M., Chiang, S. C., Bechensteen, A. G., Boelens, J. J., Heilmann, C., ... & Bryceson, Y. T. (2009). Different NK cell–activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Blood, 114(19), 4117-4127. |