Anti-Human/Mouse CD44 PE-Cyanine5

Grouped product items
Size Price Qty
25 μg
$70.00
100 μg
$160.00

Additional IM7 Formats

Cat.No. Format Starting From
06511-60 PE $ 55.00
06511-65 PE-Cyanine5 $ 70.00
06511-70 PerCP-Cyanine5.5 $ 85.00
06511-40 BG Violet 450 $ 80.00
06511-20 Purified $ 130.00
06511-50 FITC $ 55.00
06511-87 APC-Cyanine7 $ 75.00
06511-80 APC $ 60.00
06511-77 PE-Cyanine7 $ 75.00
06511-25 SAFIRE Purified $ 110.00
Catalog Number : 06511-65

description

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.

The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.

The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

Additional Information

Clone:
IM7
Format:
PE-Cyanine5
Applications:
FC
Reactivity:
Human, Mouse
Isotype:
Rat IgG2b, kappa
Research Interest: Adaptive Immunity, Angiogenesis, Stem Cell Research
Cell Type: Macrophage / Monocyte
Application: FC
Clone: IM7
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312.

Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics15(3), 313-320.

Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity13(1), 39-47.

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