Anti-Human CD80 (B7-1) FITC

Grouped product items
SizePrice Qty
25 tests
100 tests

Additional 2D10.4 Formats

Cat.No.FormatStarting From
02911-50FITC$ 90.00
02911-60PE$ 100.00
02911-25SAFIRE Purified$ 120.00
02911-30Biotin$ 200.00
02911-65PE-Cyanine5$ 145.00
02911-20Purified$ 110.00
Catalog Number : 02911-50


The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
product image
Human B lymphoblast Daudi cells were stained with FITC 2D10.4 with relevant isotype control in blue.
product image

Additional Information

Mouse IgG1, kappa
Research Interest:Innate Immunity, Adaptive Immunity
Cell Type:B Cells, Macrophage / Monocyte, T Cells, Dendritic Cells
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

Cognasse, F., Hamzeh‐Cognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y., & Garraud, O. (2008). Identification of two subpopulations of purified human blood B cells, CD27− CD23+ and CD27high CD80+, that strongly express cell surface Toll‐like receptor 9 and secrete high levels of interleukin‐6. Immunology125(3), 430-437.

Bashuda, H., Kimikawa, M., Seino, K., Kato, Y., Ono, F., Shimizu, A., ... & Okumura, K. (2005). Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. Journal of Clinical Investigation115(7), 1896-1902.

© BioGems International, Inc. All rights reserved.