Anti-Human CD45RO APC
The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.
Mouse IgG2a, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Cells, B Cells, Macrophage / Monocyte|
|Protein Cross Reactivity:||Chimpanzee|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Akbar, A. N., Terry, L., Timms, A., Beverley, P. C., & Janossy, G. (1988). Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. The Journal of Immunology, 140(7), 2171-2178.
Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E., & Beverley, P. C. (1986). Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. Immunology, 58(1), 63.