Anti-Human CD45 PE

Grouped product items
SizePrice Qty
25 tests
$75.00
100 tests
$160.00

Additional 2D1 Formats

Cat.No.FormatStarting From
07151-77PE-Cyanine7$ 110.00
07151-50FITC$ 120.00
07151-70PerCP-Cyanine5.5 $ 140.00
07151-60PE$ 75.00
07151-65PE-Cyanine5$ 110.00
Catalog Number : 07151-60

description

The 2D1 monoclonal antibody specifically reacts all isoforms of human CD45, known as the Leukocyte Common Antigen (LCA). It is expressed on lymphocytes, granulocytes, monocytes, thymocytes, and eosinophils, but not on mature erythrocytes, platelets, mature erythroid cells of bone marrow, and non-hematopoietic tissues. CD45 is essential for T cell activation and the tyrosine phosphatase activity of its intracellular region is integral for signal transduction.

Additional Information

Clone:
2D1
Format:
PE
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Adaptive Immunity
Cell Type:B Cells, NK and NKT Cells, T Cells, Macrophage / Monocyte
Application:FC
Clone:2D1
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Merkenschlager, M., & Beverley, P. C. (1989). Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45R0 (UCHL1). International Immunology1(4), 450-459.

Bikoue, A., Janossy, G., & Barnett, D. (2002). Stabilised cellular immuno-fluorescence assay: CD45 expression as a calibration standard for human leukocytes. Journal of immunological methods266(1-2), 19-32.

Pfau, J. C., Walker, E., & Card, G. L. (2000). Monoclonal antibodies to CD45 modify LPS-induced arachidonic acid metabolism in macrophages. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research1495(3), 212-222.

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