Anti-Human CD338 (ABCG2) PE

Grouped product items
SizePrice Qty
25 tests
$145.00
100 tests
$300.00

Additional 5D3 Formats

Cat.No.FormatStarting From
40411-60PE$ 145.00
Catalog Number : 40411-60

description

The 5D3 monoclonal antibody binds to CD338 (ABCG2), a multi-drug resistance (MDR) protein that is highly expressed on primitive side population stem cells, a subset of cells that express low or undetectable levels of CD34. CD338 is involved in the transport of molecules across extra- and intra-cellular membranes.

Additional Information

Clone:
5D3
Format:
PE
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG2b, kappa
Research Interest:Stem Cell Research, Angiogenesis
Cell Type:Stem Cells
Application:FC
Clone:5D3
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Özvegy-Laczka, C., Laczkó, R., Hegedűs, C., Litman, T., Várady, G., Goda, K., ... & Sarkadi, B. (2008). Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. Journal of Biological Chemistry,283(38), 26059-26070.

Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A. M., Sampath, J., Morris, J. J., ... & Sorrentino, B. P. (2001). The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature medicine7(9), 1028-1034.

Bunting, K. D. (2002). ABC transporters as phenotypic markers and functional regulators of stem cells. Stem cells20(1), 11-20.

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