Anti-Human CD279 (PD-1) APC
Catalog Number : 31831-80
description
The J105 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The lack or mutation of CD279 is linked to autoimmune disorders.
Additional Information
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Clone:
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J105
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | B Cells, T Cells |
| Application: | FC |
| Clone: | J105 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Sun, C., Kay, S., Polliack, A., Avivi, I., Wiestner, A., & Perry, C. (2017). Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia. Kim, E. J., Kwun, J., Gibby, A. C., Hong, J. J., Farris, A. B., Iwakoshi, N. N., ... & Knechtle, S. J. (2014). Costimulation Blockade Alters Germinal Center Responses and Prevents Antibody‐Mediated Rejection. American Journal of Transplantation, 14(1), 59-69. Dunham, J., van Driel, N., Eggen, B. J., Paul, C., A‘t Hart, B., Laman, J. D., & Kap, Y. S. Analysis of the cross-talk between Epstein-Barr virus-infected B cells and T cells in the marmoset. Translational multiple sclerosis research in primates, 3(4), 79. |