Anti-Human CD279 (PD-1) APC

Grouped product items
SizePrice Qty
25 tests
$160.00
100 tests
$340.00

Additional J105 Formats

Cat.No.FormatStarting From
31831-80APC$ 160.00
31831-60PE$ 155.00
Catalog Number : 31831-80

description

The J105 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The lack or mutation of CD279 is linked to autoimmune disorders.

Additional Information

Clone:
J105
Format:
APC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Adaptive Immunity
Cell Type:B Cells, T Cells
Application:FC
Clone:J105
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Sun, C., Kay, S., Polliack, A., Avivi, I., Wiestner, A., & Perry, C. (2017). Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia.

Kim, E. J., Kwun, J., Gibby, A. C., Hong, J. J., Farris, A. B., Iwakoshi, N. N., ... & Knechtle, S. J. (2014). Costimulation Blockade Alters Germinal Center Responses and Prevents Antibody‐Mediated Rejection. American Journal of Transplantation14(1), 59-69.

Dunham, J., van Driel, N., Eggen, B. J., Paul, C., A‘t Hart, B., Laman, J. D., & Kap, Y. S. Analysis of the cross-talk between Epstein-Barr virus-infected B cells and T cells in the marmoset. Translational multiple sclerosis research in primates3(4), 79.

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