Anti-Human CD243 (ABCB1) PE

Grouped product items
SizePrice Qty
25 tests
$140.00
100 tests
$330.00

Additional UIC2 Formats

Cat.No.FormatStarting From
25511-60PE$ 140.00
Catalog Number : 25511-60

description

The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp). It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.

Additional Information

Clone:
UIC2
Format:
PE
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG2a
Research Interest:Stem Cell Research
Cell Type:B Cells, NK and NKT Cells, T Cells
Application:FC
Clone:UIC2
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Mechetner, E. B., & Roninson, I. B. (1992). Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proceedings of the National Academy of Sciences89(13), 5824-5828.

Chaudhary, P. M., Mechetner, E. B., & Roninson, I. B. (1992). Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]. Blood80(11), 2735-2739.

Goda, K., Fenyvesi, F., Bacsó, Z., Nagy, H., Márián, T., Megyeri, A., ... & Szabó, G. (2007). Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. Journal of Pharmacology and Experimental Therapeutics320(1), 81-88.

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