Anti-Human CD23 PE

Grouped product items
SizePrice Qty
25 tests
$95.00
100 tests
$245.00

Additional EBVCS-5 Formats

Cat.No.FormatStarting From
05311-80APC$ 115.00
05311-60PE$ 95.00
Catalog Number : 05311-60

description

The EBVCS-5 monclonal antibody specifically binds to human CD23, a type II membrane glycoclone protein that is also called FC epsilon RII or the the low-affinity IgE receptor. It belongs to the C-type lectin structural family and plays a role in the regulation of IgE synthesis and IgE mediated activities. In addition to binding IgE, also exerts a number of IgE independent activities, such as promoting the activation and differentiation of B-cells and stimulating the release of pro-inflammatory cytokines from monocytes. CD23 is expressed on mature B cells, follicular mantle B cells, and a subset of T cells.

Additional Information

Clone:
EBVCS-5
Format:
PE
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Adaptive Immunity
Cell Type:B Cells
Application:FC
Clone:EBVCS-5
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Gordon, J., Webb, A. J., Guy, G. R., & Walker, L. (1987). Triggering of B lymphocytes through CD23: epitope mapping and studies using antibody derivatives indicate an allosteric mechanism of signalling. Immunology60(4), 517.

Gordon, J., Rowe, M., Walker, L., & Guy, G. (1986). Ligation of the CD23, p45 (BLAST‐2, EBVCS) antigen triggers the cell‐cycle progression of activated B lymphocytes. European journal of immunology16(9), 1075-1080.

Kikutani, H. I. T. O. S. H. I., Suemura, M. A. S. A. K. I., Owaki, H., Nakamura, H., Sato, R. Y. O. I. C. H. I., Yamasaki, K., ... & Kishimoto, T. A. D. A. M. I. T. S. U. (1986). Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. Journal of Experimental Medicine164(5), 1455-1469.

© BioGems International, Inc. All rights reserved.