Anti-Human CD19 PE-Cyanine5
The SJ25C1 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells. CD19 is also expressed on follicular dendritic cells, and seems to ensure the regulation of B lymphocytes proliferation. CD19, CD21, CD81, MHC class II, and Leu13 can bind together and form a complex which associates with the B cell receptor (BCR) on the surface of B lymphocytes and facilitates the signal transduction.
Mouse IgG1, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||B Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Yang, W., Agrawal, N., Patel, J., Edinger, A., Osei, E., Thut, D., ... & Meyerson, H. (2005). Diminished expression of CD19 in B‐cell lymphomas. Cytometry Part B: Clinical Cytometry: The Journal of the International Society for Analytical Cytology, 63(1), 28-35.
Korganow, A. S., Knapp, A. M., Nehme-Schuster, H., Soulas-Sprauel, P., Poindron, V., Pasquali, J. L., & Martin, T. (2010). Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression. Journal of autoimmunity, 34(4), 426-434.
Wentink, M. W., Lambeck, A. J., van Zelm, M. C., Simons, E., van Dongen, J. J., IJspeert, H., ... & van der Burg, M. (2015). CD21 and CD19 deficiency: two defects in the same complex leading to different disease modalities. Clinical Immunology, 161(2), 120-127.