Anti-Human CD19 APC
description
The SJ25C1 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells. CD19 is also expressed on follicular dendritic cells, and seems to ensure the regulation of B lymphocytes proliferation. CD19, CD21, CD81, MHC class II, and Leu13 can bind together and form a complex which associates with the B cell receptor (BCR) on the surface of B lymphocytes and facilitates the signal transduction.
Additional Information
Clone:
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SJ25C1
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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Research Interest: | Adaptive Immunity |
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Cell Type: | B Cells |
Application: | FC |
Clone: | SJ25C1 |
Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Yang, W., Agrawal, N., Patel, J., Edinger, A., Osei, E., Thut, D., ... & Meyerson, H. (2005). Diminished expression of CD19 in B‐cell lymphomas. Cytometry Part B: Clinical Cytometry: The Journal of the International Society for Analytical Cytology, 63(1), 28-35. Korganow, A. S., Knapp, A. M., Nehme-Schuster, H., Soulas-Sprauel, P., Poindron, V., Pasquali, J. L., & Martin, T. (2010). Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression. Journal of autoimmunity, 34(4), 426-434. Wentink, M. W., Lambeck, A. J., van Zelm, M. C., Simons, E., van Dongen, J. J., IJspeert, H., ... & van der Burg, M. (2015). CD21 and CD19 deficiency: two defects in the same complex leading to different disease modalities. Clinical Immunology, 161(2), 120-127. |