Anti-Human CD184 (CXCR4) APC

Grouped product items
Size Price Qty
25 tests
$170.00
100 tests
$360.00

Additional 12G5 Formats

Cat.No. Format Starting From
16911-80 APC $ 170.00
16911-60 PE $ 135.00
16911-20 Purified $ 80.00
Catalog Number : 16911-80

description

The 12G5 monoclonal antibody specifically bind to human CD184 (CXCR4), a seven-transmembrane G-protein-coupled receptor. It is widely expressed on endothelial cells, hematopietic cells, and also on naïve T cell subsets. CD184 is the receptor for SDF-1 and an alternative receptor for HIV-1. The 12G5 antibody is reported to inhibit SDF-1 induced chemotaxis and calcium influx and some CD4-dependent infections of HIV-1.

Additional Information

Clone:
12G5
Format:
APC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG2a, kappa
Research Interest: Angiogenesis, Stem Cell Research
Cell Type: T Cells, Stem Cells
Application: FC
Clone: 12G5
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., & Mackay, C. R. (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proceedings of the National Academy of Sciences,94(5), 1925-1930.

Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science272(5263), 872-877.

Simmons, G., Wilkinson, D., Reeves, J. D., Dittmar, M. T., Beddows, S., Weber, J., ... & Clapham, P. R. (1996). Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. Journal of Virology70(12), 8355-8360.

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