Anti-Human CD161 FITC
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, γδ TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
Mouse IgG1, kappa
|Research Interest:||Innate Immunity, Adaptive Immunity|
|Cell Type:||NK and NKT Cells, T Cells, Th17 cells|
|Protein Cross Reactivity:||Chimpanzee, Baboon, Rhesus|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Márquez, C., Trigueros, C., Franco, J. M., Ramiro, A. R., Carrasco, Y. R., López-Botet, M., & Toribio, M. L. (1998). Identification of a common developmental pathway for thymic natural killer cells and dendritic cells. Blood,91(8), 2760-2771.
Cosmi, L., De Palma, R., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., ... & Annunziato, F. (2008). Human interleukin 17–producing cells originate from a CD161+ CD4+ T cell precursor. The Journal of experimental medicine, 205(8), 1903-1916.
Exley, M., Porcelli, S., Furman, M., Garcia, J., & Balk, S. (1998). CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Vα24JαQ T cell receptor α chains. The Journal of experimental medicine, 188(5), 867-876.