Filipin III
Catalog Number : 4804999
description
Filipin III is the most prevalent isomer of the Filipin complex, a potent polyene macrolide antibiotic and antifungal mixture. It is reported that it functions by disrupting the cell membrane. Filipin is also used as a histochemical stain for cholesterol as it is highly fluorescent and to inhibit the raft/caveolae endocytosis pathway in mammalian cells.
Additional Information
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Applications:
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FA
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Synonyms:
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Filimirasin, Filmirisin
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Formulation:
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Crystalline solid
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Chemical Name:
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(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
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Molecular Formula:
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C35H58O11 |
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Molecular Weight: |
654.8
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CAS Number
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480-49-9
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Purity:
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≥85%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Bittman, R., & Fischkoff, S. A. (1972). Fluorescence studies of the binding of the polyene antibiotics filipin III, amphotericin B, nystatin, and lagosin to cholesterol. Proceedings of the National Academy of Sciences, 69(12), 3795-3799. Pandey, R. G., & RINEHART, K. L. (1970). POLYENE ANTIBIOTICS. V. CHARACTERIZATION OF COMPONENTS OF THE FILIPIN COMPLEX BY MASS SPECTROMETRY 1). The Journal of antibiotics, 23(8), 414-417. Orlandi, P. A., & Fishman, P. H. (1998). Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. The Journal of cell biology, 141(4), 905-915. |