EX 527
description
Additional Information
Applications:
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FA
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Synonyms:
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6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, Selisistat, EX527, SIRT1 Inhibitor III
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Formulation:
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Crystalline solid
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Chemical Name:
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6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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Molecular Formula:
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C13H13ClN2O |
Molecular Weight: |
248.7
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CAS Number
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49843-98-3
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Gertz, M., Fischer, F., Nguyen, G. T. T., Lakshminarasimhan, M., Schutkowski, M., Weyand, M., & Steegborn, C. (2013). Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.Proceedings of the National Academy of Sciences, 110(30), E2772-E2781. Solomon, J. M., Pasupuleti, R., Xu, L., McDonagh, T., Curtis, R., DiStefano, P. S., & Huber, L. J. (2006). Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Molecular and cellular biology, 26(1), 28-38. Price, N. L., Gomes, A. P., Ling, A. J., Duarte, F. V., Martin-Montalvo, A., North, B. J., ... & Sinclair, D. A. (2012). SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell metabolism, 15(5), 675-690. Kabra, N., Li, Z., Chen, L., Li, B., Zhang, X., Wang, C., ... & Chen, J. (2009). SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. Journal of Biological Chemistry, 284(27), 18210-18217. |